Clinical Mass Spectrometry

Clinical laboratory medicine has evolved and diversified over the past few decades. Although the field has seen major advancements (in terms of methodology, instrumentation, informatics, and automation) and transitions (away from conventional immunoassays), mass spectrometry (MS) is now utilised across several areas of diagnostics. This encompasses therapeutic drug monitoring, toxicology and endocrinology testing.

MS is a fundamental and versatile technique for such analyte measurements due to its sensitivity, specificity, throughput and multiplexicity. Therefore, Stable isotope-labelled (SIL) standards are integral to this analysis, as noted by the references below. Another example is the Researcher Perspective from Doctors Braunstein and Tim West (C2N Diagnostics), which provides an overview of the stable isotope labelling kinetic (SILK™) assay developed to measure blood-derived protein biomarkers, such as Aβ isoforms, involved in Alzheimer’s disease and to track its progression.

Cambridge Isotope Laboratories, Inc. is proud to offer a variety of analytical standards for identification/quantification in clinical MS samples. These standards are highly characterised for analytical purposes, suitable for use in a variety of sample types, and available in various packaging sizes and formats.